The Impact of Sodium Selenite and Seleno-L-Methionine on Stress Erythropoiesis in a Murine Model of Hemolytic Anemia.

• Tác giả: Yuting Bai, Hangdi Gong, Robert F Paulson, K Sandeep Prabhu, Dane Rahoi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.152 *Anemia
• Thông tin xuất bản: United States : The Journal of nutrition , 2025
• Bộ sưu tập: NCBI
• ID: 678045

Tóm tắt

 BACKGROUND: Selenium (Se) is an essential trace element that exerts most biological activities through selenoproteins. Dietary selenium is a key regulator of red cell homeostasis and stress erythropoiesis. However, it is unknown whether the form and increasing doses of Se supplementation in the diet impact stress erythropoiesis under anemic conditions. OBJECTIVES: If inorganic (sodium selenite
  Na METHODS: Three-wk-old male C57BL/6 mice were subjected to graded amounts of Se in the form of <
 0.01 mg/kg Se [Se-deficiency (Se-D)], 0.1 mg/kg Na RESULTS: Phenotypic parameters showed that supplementing the diet with Se in the form of Na