Regulation of nucleus-encoded trans-acting factors allows orthogonal fine-tuning of multiple transgenes in the chloroplast of Chlamydomonas reinhardtii.

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Tác giả: Kitty Clouston, Katrin Geisler, Aleix Gorchs-Rovira, Payam Mehrshahi, Pawel Mateusz Mordaka, Alison Gail Smith, Catherine Sutherland, Daniel Qingyang Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 959.3031 *Thailand

Thông tin xuất bản: England : Plant biotechnology journal , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 678212

The green microalga Chlamydomonas reinhardtii is a promising host organism for the production of valuable compounds. Engineering the Chlamydomonas chloroplast genome offers several advantages over the nuclear genome, including targeted gene insertion, lack of silencing mechanisms, potentially higher protein production due to multiple genome copies and natural substrate abundance for metabolic engineering. Tuneable expression systems can be used to minimize competition between heterologous production and host cell viability. However, complex gene regulation and a lack of tight regulatory elements make this a challenge in the Chlamydomonas chloroplast. In this work, we develop two synthetic tuneable systems to control the expression of genes on the chloroplast genome, taking advantage of the properties of the vitamin B
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