Toxicity assessment of titanium dioxide nanoparticles on microorganisms through topological data analysis of high dimensional single-cell nanomechanical data.

• Tác giả: Ludovic Duponchel, Jérôme F L Duval, Marc Offroy, Christophe Pagnout, Angelina Razafitianamaharavo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 006.312 Data mining
• Thông tin xuất bản: Netherlands : Talanta , 2025
• Bộ sưu tập: NCBI
• ID: 678258

Tóm tắt

There is a growing interest in the development of methods for the detection of nanoparticle (NP) toxicity to living organisms based on the analysis of relevant multidimensional data sets. In particular the detection of preliminary signs of NPs toxicity effects would benefit from the selection of data featuring NPs-induced alterations of biological barriers. Accordingly, we present an original Topological Data Analysis (TDA) of the nanomechanical properties of Escherichia coli cell surface, evaluated by multiparametric Atomic Force Microscopy (AFM) after exposure of the cells to increasing concentrations of titanium dioxide nanoparticles (TiO