In vitro activity of omadacycline against geographically diverse rapidly growing nontuberculous mycobacteria (NTM) clinical isolates.

• Tác giả: Diane M Anastasiou, Akio Aono, Satoshi Mitarai, Alisa W Serio, Eva Terschlüsen, Jakko van Ingen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.85262 Diseases of nervous system and mental disorders
• Thông tin xuất bản: United States : Diagnostic microbiology and infectious disease , 2025
• Bộ sưu tập: NCBI
• ID: 678692

Tóm tắt

Nontuberculous mycobacteria (NTM) are emerging opportunistic pathogens with limited treatment options due to resistance to multiple antibiotic classes. This study aimed to evaluate the in vitro activity of omadacycline and comparator antibiotics against rapidly growing mycobacteria (RGM) clinical isolates. Minimum inhibitory concentration (MIC) evaluation of RGM clinical isolates was performed by two independent laboratories (EU and Japan). A total of 383 isolates (211 EU, 172 Japan) were evaluated. Omadacycline was active against all RGM species tested. For Mycobacterium abscessus subsp. abscessus, MIC