Identification of novel KRAS

• Tác giả: Siyin Chen, Tong Chen, Xiaojian Han, Xiaxia Han, Yanan Hao, Jingjing Huang, Aishun Jin, Luo Li, Shengchun Liu, Meiying Shen, Bozhi Wang, Wang Wang, Lin Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: England : Journal of translational medicine , 2025
• Bộ sưu tập: NCBI
• ID: 678820

Tóm tắt

BACKGROUND: T cell receptor (TCR)-engineered T cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes in clinical trials against solid tumors. However, the challenge lies in developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize the possibility of severe clinical toxicities. Current research efforts have been put towards strategies to eliminate TCR off-target recognition. METHODS: Naive T cell repertoire was used for screening KRAS RESULTS: HLA-A*11:01-restricted TCRs targeting the KRAS CONCLUSIONS: TCRs targeting the KRAS