Diagnostic utility of next-generation sequencing in neurological infections: Two cases in point.

• Tác giả: Ravi Teja Kandikuppa, Vidya Krishna, Srinivasan Paramasivam, Nandini Sethuraman, Anuradha Sridhar
• Ngôn ngữ: eng
• Ký hiệu phân loại: 912.01 Philosophy and theory
• Thông tin xuất bản: United States : Diagnostic microbiology and infectious disease , 2025
• Bộ sưu tập: NCBI
• ID: 679165

Tóm tắt

We report the successful management of two cases of brain abscess and subdural empyema caused by Fusobacterium nucleatum and Streptococcus intermedius diagnosed using 16S ribosomal RNA (rRNA) sequencing where microbiological culture showed no growth. This report elucidates the utility of next-generation sequencing (NGS) in determining the microbial etiology and guiding appropriate antimicrobial treatment in life-threatening neurological infections.