Detection rate of herpes simplex virus DNA in the lower respiratory tract of critical care patients with or without coinfection determined by the Biofire® pneumonia plus panel.

• Tác giả: Eliseo Albert, Sofía Cano, Nieves Carbonell, María Ángeles Clari, David Navarro, Beatriz Quevedo Sánchez, Elena Villar
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.51 *Head
• Thông tin xuất bản: United States : Diagnostic microbiology and infectious disease , 2025
• Bộ sưu tập: NCBI
• ID: 679231

Tóm tắt

We investigated whether the results returned by the Biofire® Pneumonia Plus Panel (FA-PP) in lower respiratory tract specimens (LRT) specimens may identify patients who should be targeted for Herpes simplex virus (HSV) DNA testing. We included 35 adult ICU patients who underwent protocolized HSV DNA testing in LRT and/or plasma specimens by real-time PCR. Of these, one patient underwent allogeneic hematopoietic cell transplantation, one a kidney transplantation and one was under CAR-T cell therapy. Twenty-three of the 33 patients (69.6 %) had HSV-type 1 (HSV-1) DNA detected in LRT specimens (median viral load: 5.67 log