Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis.

• Tác giả: Andrea Adamcakova-Dodd, Fei Chen, Ranakul Islam, Ke Jian Liu, Ling-Zhi Liu, Jia Luo, Peter S Thorne, Yi-Fang Wang, Lei Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Ecotoxicology and environmental safety , 2025
• Bộ sưu tập: NCBI
• ID: 679762

Tóm tắt

Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. However, the role and mechanism of COX-2 in Cr(VI)-induced carcinogenesis are not clear yet. To address this question, we employed a mouse model exposed to Cr(VI) through intranasal instillation of particulate zinc chromate (ZnCrO