SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO.

• Tác giả: Anisah Adeagbo, Elisa Aquilanti, Nolan Bick, Ashir A Borah, Patricia C Borck, Isabella Boyle, Catarina D Campbell, Edmond M Chan, Tessla Chan, Sohani Das Sharma, Joshua M Dempster, Kyla Foster, Todd R Golub, Kristina Jankovic, Riya V Kishen, J Michael Krill-Burger, Anthony C Lau, Tianxia Li, Nicholas J Lofaso, Daniel A Lubicki, Lucy I Parker-Burns, John R Prensner, Srivatsan Raghavan, Francisca Vazquez
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature , 2025
• Bộ sưu tập: NCBI
• ID: 679774

Tóm tắt

Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer cells. Various inhibitors of such synthetic lethal targets have been approved by the FDA or are in clinical trials, highlighting the potential of this approach