The chemical fractionation and environmental risk of Ba, Co, Cu, Mn, Mo, Ni, and Pb were evaluated in drill cuttings (DCs) from onshore and offshore oil and gas exploration wells at different depths. The metal concentration in each fraction was determined using inductively coupled plasma mass spectrometry (ICP-MS) after employing the Community Bureau of Reference (BCR) sequential extraction procedure. The method's accuracy was assessed by analyzing a certified reference material, in which the recovery concentrations after the fractionation ranged from 81.9% to 125%. In both onshore and offshore wells, Ba and Mn had higher contents in DCs. The metal determination for the onshore well was mainly found in the F4 fraction (after acid digestion). For the offshore well, the main metal determination was in the F2 fraction (iron and manganese oxides) and the F3 fraction (organic matter). Multivariate analysis revealed that, in offshore samples evaluated at different depths, the extraction medium exerts a greater influence on metal availability than the geochemical behavior of the samples as a function of depth. On the other hand, the opposite behavior was observed in onshore samples. The environmental analysis of the samples indicated high contamination, particularly for Ba, Mn, and Pb, while the cumulative metal pollution was associated with the depth of the wells.