Acetalax and Bisacodyl for the Treatment of Triple-Negative Breast Cancer: A Combined Molecular and Preclinical Study.

• Tác giả: Ahmed Dahmani, Rania El Botty, Fathi Elloumi, Léa Huguet, Samuel Huguet, Augustin Luna, Elisabetta Marangoni, Makito Mizunuma, Remi Montagne, Ludivine Morriset, Yves Pommier, William C Reinhold, Keyvan Rezai, Naoko Takebe, Sudhir Varma, Yanghsin Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 272.3 Persecutions of Waldenses and Albigenses
• Thông tin xuất bản: United States : Cancer research communications , 2025
• Bộ sưu tập: NCBI
• ID: 679922

Tóm tắt

Acetalax and bisacodyl represent a prospective novel drug mechanism-of-action type, affect mitochondrial function and affect tumor growth in vivo. Their activity may be predicted by TRPM4 but with more accuracy adding other genes in multivariate analysis for triple negative breast cancer (TNBC). Acetalax has a biphasic mean half-life of 5.8 hours.