Single incretin receptor knockout mice do not compensate by increasing glucose-stimulated secretion of the remaining incretin hormone.

• Tác giả: Alice Bazzichi, Katrine D Galsgaard, Jens J Holst, Sara L Jepsen, Hannelouise Kissow, Mark M Smits, Jon Vergara
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.926 *Trionychidae (Soft-shelled turtles), Carettochelyidae (New Guinea plateless turtle), Dermatemydidae, Platysternidae
• Thông tin xuất bản: United States : American journal of physiology. Endocrinology and metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 680023

Tóm tắt

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones. Lack of GLP-1 receptor signaling has been reported to be compensated for by increased GIP secretion and action. Conversely, GLP-1 sensitivity has been reported to be increased in GIP receptor knockout (