BACKGROUND: Evidence suggests that environmental factors may influence the risk of ischemic stroke(IS). METHOD: In this study, we employed an approach known as convergent cross-mapping to identify and elucidate the causal effects of significant air pollutants and meteorological factors on the pathogenesis of IS. The city of Shouguang in the Shandong Peninsula region was selected for this study, primarily because of the environmental characteristics of the region and the notable prevalence of cases during the study period. RESULTS: Key air pollutants and several meteorological factors in the region have a causal effects on IS. A general trend can be drawn. SO CONCLUSION: Through this case study, a causal network was developed with the aim of integrating the study of the interactions between variables and providing a clear model to aid the management of IS.