Probiotics reverse gut dysbiosis and memory impairment associated with esomeprazole use in chronically stressed rats: A significant neuroprotective role for cholecystokinin.

• Tác giả: Lamiaa A Ahmed, Reem M Eladawy, Rehab M El-Sayed, Ahmed F Mohamed, Hesham A Salem, Maha B Salem
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.7968 Land, recreational and wilderness areas, energy
• Thông tin xuất bản: Netherlands : International immunopharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 680092

Tóm tắt

Recent studies propose an association between the prolonged usage of gastric acid suppressants (GAS) and the incidence of dementia in stressed patients. This association was confirmed in our investigation recently published with a significant role for gut dysbiosis using different GAS, especially PPI esomeprazole (Esom). Hence, this work explored the influence of different probiotics on gut dysbiosis associated with Esom use in unpredictable chronic mild stress (UCMS)-induced cognitive impairment. Rats were given Esom (3.7 mg/kg/day orally) with exposure to UCMS for 7 weeks and treated with Lactobacillus delbrukii and Lactobacillus fermentum (LB) (1 × 10