Nutritionally responsive PMv DAT neurons are dynamically regulated during pubertal transition.

• Tác giả: Nicole Bellefontaine, Christian Broberger, Jose Donato, Carol F Elias, Chelsea N Fortin, Renata Frazao, Laura Heikkinen, Cristiano Mendes-da-Silva, Cristina Sáenz de Miera, Marina A Silveira, Kevin W Williams, Thais T Zampieri
• Ngôn ngữ: eng
• Ký hiệu phân loại: 338.8890921 Combinations
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 680329

Tóm tắt

UNLABELLED: Pubertal development is tightly regulated by energy balance. The crosstalk between metabolism and reproduction is orchestrated by complex neural networks and leptin action in the hypothalamus plays a critical role. The ventral premammillary nucleus (PMv) leptin receptor (LepRb) neurons act as an essential relay for leptin action on reproduction. Here, we show that mouse PMv cells expressing the dopamine transporter (DAT) gene, SIGNIFICANCE STATEMENT: Women with excess or low energy stores ( GRAPHICAL ABSTRACT: The ventral premammillary nucleus of the hypothalamus plays an essential role in the metabolic control of reproduction. Puberty brings large changes to a subpopulation of PMv