Mechanistic studies on pH-permeability relationships: Impact of the membrane polar headgroup region on pKa.

• Tác giả: Paul Anthony, Wayne Childers, Md Hridoy, Irfan Khan, Ken Korzekwa, Swati Nagar, Mercy Ramanjulu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 382.53 Embargoes on imports
• Thông tin xuất bản: Netherlands : International journal of pharmaceutics , 2025
• Bộ sưu tập: NCBI
• ID: 680466

Tóm tắt

Passive permeability through biological membranes requires partitioning of drug molecules into the lipid bilayer and subsequent permeation. Most drugs are weak acids or bases, making their ionization constants (pK