AIM: The study aimed to investigate the relationship between existential anxiety, posttraumatic growth, and resilience in nurses working in COVID-19units. DESIGN: The study was a descriptive-analytical study. METHODS: The researchers conducted the study on 224 nurses working in the COVID-19units of four hospitals affiliated with Kerman University of Medical Sciences in Southeast Iran from 2021 to 2020 with census method. the data were collected using a demographic questionnaire, Masoudi Sani et al.'s existential anxiety questionnaire, the Conner-Davidson resilience scale, posttraumatic growth inventory. RESULTS: The mean age of nurses were 30.88% ± 6.53% and 76.3% of them were female. The results showed there were a negative and significant correlation between posttraumatic growth and resilience ( CONCLUSION: The results demonstrated that the mean scores of existential anxiety, resilience and posttraumatic growth were moderate. The researchers suggest educational and interventional measures to improve resilience, posttraumatic growth and reduce existential anxiety among nurses.