M8OI toxicity is associated with an inhibition of ubiquinone reduction by complex I in the mitochondrial electron transport chain.

• Tác giả: Tarek M Abdelghany, Fahad A Aljehani, Omar H Alkhathami, Jessica Bosak, Agnieszka K Bronowska, Alex Charlton, Lanyu Fan, Shireen A Hedya, Judy Hirst, Alistair C Leitch, Satomi Miwa, Matthew C Wright
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Chemosphere , 2025
• Bộ sưu tập: NCBI
• ID: 680486

Tóm tắt

Methylimidazolium ionic liquids (MILs) are solvents used in an increasing variety of industrial applications. Recent studies identified the 8C MIL (M8OI) contaminating the environment, detected exposure in humans and proposed M8OI to be a potential trigger for the autoimmune liver disease primary biliary cholangitis (PBC). To gain a better understanding of any PBC trigger mechanism(s), the interaction of M8OI with mitochondria has been examined. M8OI inhibited oxygen consumption in intact cells and induced cell death (IC