Gastroretentive microballoons of olmesartan medoxomil: formulation and

• Tác giả: Shweta Aloshi, Yadishma Gaude, Rajashree S Masareddy, Archana S Patil
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Therapeutic delivery , 2025
• Bộ sưu tập: NCBI
• ID: 680676

Tóm tắt

BACKGROUND: Olmesartan medoxomil, classified as BCS class II due to its poor water solubility, exhibits a low oral bioavailability of 28.6%. MATERIALS AND METHODS: Microballoons of Olmesartan medoxomil were formulated using the ionotropic gelation technique and subjected to various evaluation parameters. RESULTS: The particles were found to be in the range of 85.11 to 312.6 µm. The prepared microballoons remained buSSoyant for more than 12 hours and showed percentage of cumulative drug release between 56.32-83.62%. CONCLUSION: The formulated microballoons (hollow microspheres) emerged as a promising option for an oral gastro retentive controlled drug delivery system for Olmesartan medoxomil.