A polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging.

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Tác giả: Allison A Appleton

Ngôn ngữ: eng

Ký hiệu phân loại: 758.3 *Animals

Thông tin xuất bản: United States : Epigenetics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 680868

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Gestational epigenetic aging (GEA) is a novel approach for characterizing associations between prenatal exposures and postnatal risks. Psychosocial adversity in pregnancy may influence GEA, but the molecular mechanisms are not well understood. DNA methylation to glucocorticoid regulation and hypothalamic-pituitary-adrenal (HPA) axis genes are implicated but have not been fully examined in association with GEA. This study investigated whether a polyepigenetic glucocorticoid exposure score (PGES) and HPA axis gene (

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