OBJECTIVE: Various immune-cell subsets intricately mediate the pathogenesis of systemic lupus erythematosus (SLE). However, the role of CD8 METHODS: We retrospectively enrolled 211 patients with SLE and 48 age- and sex-matched healthy controls (HCs). Peripheral CD8 RESULTS: Patients with SLE (mean age, 42.3 years
women, 89% and mean disease duration, 112.8 months) had significantly higher proportions of naïve CD8 CONCLUSION: In SLE, greater proportions of highly cytotoxic and proinflammatory activated CD8