BACKGROUND: Ebola-HIV and malaria co-infection is one of the rare clinical situations that remains complex to manage even in the context of unlimited resources. In pregnancy, each of these infections can compromise maternal and fetal outcomes. The synergy of their effects on maternal immunity are often fatal, and survival is an exception, especially in a context of limited resources, such as in Ebola Treatment Units (ETUs). CASE PRESENTATION: Our 22-year-old patient, weighing 56 kg and nine weeks pregnant was admitted to the ETU during the 10th outbreak in DRC. She had HIV and had abandoned antiretroviral treatment (ART) seven months before. One month before her admission, her HIV viral load was high with a low CD4 CONCLUSION: In case of Ebola, HIV and malaria co-infection, maternal and fetal survival remains possible even in the context of resources limited-setting. This case raises questions about the effects of the interactions of these co-infections and/or their antibodies, treatment during immune adaptation of the gravid organism.