BACKGROUND: This study investigated the mediating role of hope in the relationship between anxiety and fatigue in family caregivers of individuals with dementia. METHODS: A cross-sectional design was employed, with data collected from 84 family members caring for a patient with dementia in Tzu Chi Hospital in eastern Taiwan. Instruments were the Herth Hope Index, fatigue, and anxiety scales. RESULTS: The findings revealed a significant negative correlation between fatigue and hope (r = -.431, p <
.01), a significant positive correlation between fatigue and anxiety (r =.584, p <
.01), and a significant negative correlation between hope and anxiety (r = -.364, p <
.01). Furthermore, the results indicated that anxiety indirectly predicted fatigue through hope. Hope was a mediating variable between anxiety and fatigue, accounting for 15.6% of the mediating effect. CONCLUSIONS: Prioritizing the physical and mental health of family caregivers of individuals with dementia by fostering hope can help alleviate their caregiving fatigue and enhance their overall well-being.