A bilayer scaffold of collagen and nanohydroxyapatite promotes osteochondral defect in rabbit knee joints.

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Tác giả: Bin Cao, Fulin Chen, Zhuoyue Chen, Yayuan Guo, Shen Li, Qian Liu, Xueliang Peng, Shequn Zhang, Dalong Zhi

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Bone & joint research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 681433

 AIMS: A large number of surgical operations are available to treat osteochondral defects of the knee. However, the knee joint arthroplasty materials cannot completely mimic the articular cartilage and subchondral bone, which may bring some obvious side effects. Thus, this study proposed a biocompatible osteochondral repair material prepared from a double-layer scaffold of collagen and nanohydroxyapatite (CHA), consisting of collagen hydrogel as the upper layer of the scaffold, and the composite of CHA as the lower layer of the scaffold. METHODS: The CHA scaffold was prepared, and properties including morphology, internal structure, and mechanical strength of the CHA scaffold were measured by scanning electron microscopy (SEM) and a MTS electronic universal testing machine. Then, biocompatibility and repair capability of the CHA scaffold were further evaluated using a rabbit knee cartilage defect model. RESULTS: The CHA scaffold was well suited for the repair of articular cartilage and subchondral bone
  the in vitro results showed that the CHA scaffold had good cytocompatibility. In vivo experiments demonstrated that the material had high biocompatibility and effectively induced cartilage and subchondral bone regeneration. CONCLUSION: The CHA scaffold has a high potential for commercialization and could be used as an effective knee repair material in clinical applications.
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