INTRODUCTION: The provision of well-woman services to women is a very good intervention for promoting good health and well-being among women. Despite data needed to inform increasing accessibility to well-woman services, there is limited information about client's satisfaction with well-woman services. OBJECTIVE: This study was conducted to determine factors influencing women's satisfaction with well-woman services at Manhyia Government Hospital. DESIGN: An analytical cross-sectional study was conducted among women attending the well-woman clinic at the Manhyia Government Hospital, Kumasi from 10 May 2023 to 15 November 2023. METHODS: A systematic sampling method was employed. A pretested structured questionnaire was used to collect data on participants' socio-demographic and clinical characteristics, health-facility-related factors, barriers to utilization and client satisfaction. A face-to-face interview was conducted for every woman included in the study. Data were analyzed using multivariable logistic regression analysis. RESULTS: Of the 344 women who were recruited for the study, majority (65.7%) of them were satisfied with care at the well-woman clinic. About 59.3% of the women were willing to continue care at the clinic. The age range was 18-60 with mean of 34.6 ± 12.0 years. Some of the challenges the women reported in accessing well-woman services at the clinic included long waiting times (17.7%) and inadequately skilled staff (8.1%). After adjusting for significant variables in the multivariable logistic regression analysis (adjusted odds ratio (AOR)), comfortability of the waiting area (AOR: 7.71, 95% CI: 1.54-38.60), <
6 months duration of accessing care (AOR: 8.82, 95% CI: 3.25-23.98) and friendly attitude of health workers (AOR: 27.03, 95% CI: 4.28-170.83) were significantly associated with the client's satisfaction with well-woman services. CONCLUSION: There was high satisfaction with well-woman services at the clinic, and this was associated with factors such as duration of service, comfortability of the waiting area and the attitude of health workers. Training more skilled staff and expanding the clinic will help improve well-woman services.