BACKGROUND/OBJECTIVE: Although breastfeeding is safe in women with systemic lupus erythematosus (SLE) who take breastfeeding-compatible medications, rates of breastfeeding are inconsistent, and little is known about the lived experiences surrounding infant feeding among women with SLE. In this qualitative study, we identified factors that influence infant feeding practices of these women. METHODS: Using a phenomenological approach, we conducted and thematically analyzed semi-structured interviews on infant feeding practices with adult women with SLE evaluated at a single tertiary care musculoskeletal center who had given birth within the last 6 years. We collected and summarized maternal, SLE disease, and pregnancy characteristics using descriptive statistics. RESULTS: Semi-structured interviews were conducted among 19 women with SLE with mean age of 36.1 years at delivery. We identified four overarching themes: general considerations related to infant feeding, medical considerations related to infant feeding, perspectives on infant feeding, and messages to peers with SLE and healthcare providers. CONCLUSIONS: We identified both SLE-specific and disease-agnostic factors impacting infant feeding behaviors in women with SLE. SLE-specific factors influencing infant feeding practices should be viewed holistically within the context of individuals' personal preferences, which in turn may be shaped by interpersonal and cultural factors. Our findings can inform shared decision-making related to infant feeding practices in women with SLE, as well as tailored educational strategies to meet their unique needs.