Prebiotic formation of thioesters via cyclic anhydrides as a key step in the emergence of metabolism.

• Tác giả: Véronique Blandin, Abdelkarim El Qami, Oscar Gayraud, Jorge Isaac Hilari, Anne Milet, Yannick Vallée
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 681905

Tóm tắt

Thioesters are high-energy derivatives of carboxylic acids that are essential in the functioning of today's living cells. Their central role argues in favor of their early introduction in the abiotic reaction network which led to the emergence of life on Earth. We propose that the first thioesters appeared during the establishment of the reverse tricarboxylic acid (rTCA) cycle, an effective metabolic cycle for the synthesis of organic molecules from CO