Vitamin D does not reduce depressive symptoms on primary depression: Critical appraisal and re-analysis of Wang et al.

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Tác giả: Bernardo Paim de Mattos, Igor Eckert

Ngôn ngữ: eng

Ký hiệu phân loại: 629.134352 Aerospace engineering

Thông tin xuất bản: Netherlands : Journal of affective disorders , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 681926

In this critical appraisal of a meta-analysis on vitamin D for primary depression, we uncovered several methodological issues, including deviations from stated eligibility criteria, questionable analytical decisions, and the omission of a high-quality clinical trial in the subgroup analyses that supported their main conclusions. Our revised meta-analysis found no evidence of subgroup differences and no statistically significant effects within either subgroup. Moreover, we identified two influential outliers that overstate the effect favoring vitamin D. These findings suggest that the conclusions drawn by Wang et al. were influenced by an incorrect interpretation of a flawed analysis. Our findings suggest that vitamin D supplementation does not appear to confer a clinically meaningful benefit for reducing depressive symptoms, regardless of patients' baseline vitamin D status.
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