A novel automated IHC staining system for quality control application in ALK immunohistochemistry testing.

• Tác giả: Chengdong Chang, Hongwei Chen, Rui Guo, Chunxiao Hou, Cheng Li, Jinfeng Lu, Haiyan Qu, Xueru Song, Jingyi Xu, Liming Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 297.1248 Sources of Islam
• Thông tin xuất bản: Switzerland : Pathology oncology research : POR , 2025
• Bộ sưu tập: NCBI
• ID: 682345

Tóm tắt

The establishment of positive and negative controls in immunohistochemistry (IHC) screening for anaplastic lymphoma kinase (ALK) rearrangements is essential in the treatment of lung adenocarcinoma. However, positive control of patient tissue is rare and comes with ethical issues. A novel automated solution for ALK IHC quality control management was investigated by comparison with the established D5F3 antibody on the VENTANA system in 87 lung adenocarcinoma specimens with known ALK status re-analyzed by fluorescence