BACKGROUND AND AIMS: Recent studies reported that non-invasive imaging techniques for measuring optic nerve sheath diameter (ONSD) offer a novel diagnostic approach for intracranial pressure (ICP) elevation. However, whether ultrasound-measured ONSD sensitively evaluate the real-time ICP is unknown. This study explores the ability of different measurement modalities to predict ICP elevation, aiming to provide a superior non-invasive ICP monitoring technique for clinical practice. METHODS: Optic nerve sheath (ONS) measurement using three modalities and ICP of 104 patients collected from January 2018 to May 2021 were analysis by correlation analysis and receiver operating characteristic curve analysis. RESULTS: Significant correlations were observed between ICP and ONS measurement using three modalities ( CONCLUSION: Ultrasonic transverse scanning, longitudinal scanning, and area-based measurement of the retrobulbar ONS are excellent screening tools for the diagnosis of ICP. These three methods exhibited nearly identical levels of correlation, sensitivity, and specificity. All three measurement approaches demonstrated capabilities in diagnosing elevated ICP.