Two-Step Constitutional Isomerization of Saturated Cyclic Amines Using Borane Catalysis.

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Tác giả: Charis Amber, Julius Domack, Timothée M Petitjean, Richmond Sarpong, Giedre Sirvinskaite, David W Small, Breanna Sprague, Ryan T Steele

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : JACS Au , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 682498

The prevalence of saturated azacycles within pharmaceuticals, natural products, and agrochemicals has prompted the development of many methods that modify their periphery. In contrast, technologies that interconvert distinct saturated azacyclic frameworks, which would uniquely facilitate access to underexplored chemical space, are highly limited. Existing approaches for modifying the core of azacycles usually require either the installation of reactive functionality, which must later be removed in subsequent steps, or the use of tailored substrates, limiting applicability to drug discovery. Herein, we report a borane-catalyzed contraction of saturated
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