The Pro-vs. Anti-Angiogenic Capacity of Short Chain Fatty Acids is Dependent on the Bioavailability of FFAR3 in Peripheral Artery Disease.

• Tác giả: Vijay Ganta, Sivaraman Kuppuswamy, Kripa Patel, Wenbo Zhi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 782.292 *Chant
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 682577

Tóm tắt

BACKGROUND: Our current study builds on our recent report that showed Palmitate aggravates ischemic endothelial (EC) dysfunction METHODS: Femoral artery ligation and resection was used as preclinical-PAD model. Hypoxia serum starvation was used as RESULTS: Palmitate dramatically decreased ischemic-EC survival and angiogenic capacity CONCLUSIONS: Our data shows that Palmitate alone is not sufficient to drive the PAD severity. Increased FFAR3 levels in ischemic-muscle allow SCFAs to activate the AKT-NO axis to induce ischemic angiogenesis and perfusion recovery. However, loss of FFAR3 in ischemic-muscle promotes FFAR2 activation that blocks SCFA-induced NO-production and redox balance thereby inhibiting perfusion recovery in preclinical-PAD.