Reference Library for Suspect Non-targeted Screening of Environmental Toxicants Using Ion Mobility Spectrometry-Mass Spectrometry.

• Tác giả: Noor A Aly, Erin S Baker, Evan E Bolton, James N Dodds, Kara M Joseph, Ivan Rusyn, Emma L Schymanski, Devin Teri, Paul A Thiessen, Antony J Williams, Jian Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 682627

Tóm tắt

As our health is affected by the xenobiotic chemicals we are exposed to, it is important to rapidly assess these molecules both in the environment and our bodies. Targeted analytical methods coupling either gas or liquid chromatography with mass spectrometry (GC-MS or LC-MS) are commonly utilized in current exposure assessments. While these methods are accepted as the gold standard for exposure analyses, they often require multiple sample preparation steps and more than 30 minutes per sample. This throughput limitation is a critical gap for exposure assessments and has resulted in an evolving interest in using ion mobility spectrometry and MS (IMS-MS) for non-targeted studies. IMS-MS is a unique technique due to its rapid analytical capabilities (millisecond scanning) and detection of a wide range of chemicals based on unique collision cross section (CCS) and mass-to-charge (