RNA Modifications and Prp24 Coordinate Lsm2-8 Binding Dynamics during

• Tác giả: Samuel E Butcher, Aaron A Hoskins, Ye Liu, Yuichiro Nomura
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.1074 Engineering mechanics and materials
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 682688

Tóm tắt

 In eukaryotes, the process of intron removal from nuclear pre-mRNA is performed by the spliceosome, a dynamic molecular machine composed of small nuclear ribonucleoproteins (snRNPs
  U1, U2, U4, U5, and U6) and dozens of other protein splicing factors. The U6 snRNP contains the U6 snRNA and the proteins Prp24 and Lsm2-8 heteroheptamer. A key feature of the snRNP is a modified U6 snRNA 3' end, which in