PLXNB1 and other signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease.

• Tác giả: Lisa Barnes, David Bennett, Kristen J Brennand, Kevin Chen, Natacha Comandante-Lou, Philip L De Jager, Roland H Friedel, Masashi Fujita, Sarah Heuer, Bin Hu, Hans-Ulrich Klein, Tsering Lama, Aiqun Li, Shuhui Liu, Yiyi Ma, Vilas Menon, Julie Schneider, Mariko Taga, Minghui Wang, Tracy Young-Pearse, Bin Zhang, Jinglong Zhang, Ya Zhang, Hongyan Zou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.831 *Alzheimer disease
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 682723

Tóm tắt

Alzheimer's disease (AD) is marked by the coordinated emergence of disease-associated cell states across multiple cell types. Here, we first performed a meta-analysis of single-nucleus transcriptomic (snRNAseq) data from 869 brains of diverse decedents, confirming the critical role of an