Evidence that glycopolymer transferases promote peptidoglycan hydrolysis in

• Tác giả: Jennifer D Cohen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 649.48 Substance abuse
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 682768

Tóm tắt

Most bacteria are encased in a rigid cell wall peptidoglycan (PG) meshwork. Cell growth requires the activities of both PG synthases and PG hydrolases that cleave bonds within the meshwork enabling its expansion. PG hydrolase activity must be carefully regulated to prevent excessive damage to this protective layer leading to catastrophic lysis. Here, I provide evidence for a novel type of regulation mediated by lipid-linked glycopolymer precursors. The Gram-positive bacterium