Photothermal therapy (PTT) has emerged as an effective cancer treatment strategy, which utilizes photothermal agents that accumulate at tumor sites and induce localized hyperthermia when irradiated. Near-infrared II (NIR II) fluorophores, such as the polymethine cyanine-based photothermal dye IR1061, exhibit higher temporal resolution and better tissue penetration, thereby making them promising candidates for PTT. However, challenges such as the low water solubility and