INTRODUCTION: This study aimed to evaluate the efficacy and safety of a 595 nm pulsed dye laser (PDL) for the treatment of port wine stain (PWS) in 120 Asian infant patients. METHODS: A retrospective analysis was carried out to assess the efficacy and safety of 595 nm PDL in 120 Asian infant patients with PWS. RESULTS: This study identified excellent (21.67%), good (23.33%), fair (30.83%), and poor (15.83%) clearance. Multiple treatments significantly improved efficacy, with 61.56% of patients achieving good or excellent responses after more than six sessions. Younger patients showed better treatment outcomes than older patients did. The lesion location influenced the response, with leg lesions exhibiting the poorest response. The pink lesions were the most susceptible, whereas the purple lesions displayed the least response. Smaller lesions (<
10 cm²) showed a size-dependent excellent rate (41.0%) and lower poor rate (5.1%). CONCLUSION: The 595 nm PDL treatment displayed a favorable safety profile, with only mild, well-tolerated adverse effects. Rare adverse effects were resolved within 3-6 months. No severe adverse events were reported. The 595 nm PDL is safe and effective for Asian infant patients with PWS. The side effects were mild and well-tolerated by the patients.