JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G.

• Tác giả: Jason Aligo, Lorraine Angelillo, Diana Alvarez Arias, Aleksandra Brajic, Dirk Brehmer, Regina J Brown, Kristel Buyens, Gerald Chu, Jacalyn Clawson, Brian Geist, James G Greger, Yoshitomo Hamuro, Julien Häsler, Stephen Jarantow, Sylvie Laquerre, Josh Lauring, Laurie Lenox, Matthew V Lorenzi, Krista Menard, Nataša Obermajer, Maté Ongenaert, Kathryn Packman, Jaymala Patel, Ted Petley, Katharine Rogers, Keith Schutsky, Tsun-Wen Sheena Yao, Jacintha Shenton, Sanjaya Singh, Ken Tian, Vince Torti, Kelly van de Ven, Marjolein van Heerden, Bie Verbist, Shana Versmissen, Dan Weinstock, Fang Yi, Adam Zwolak
• Ngôn ngữ: eng
• Ký hiệu phân loại: 625.763 Snow and ice control measures
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 683106

Tóm tắt

T cell-redirecting bispecific antibodies (bsAbs) to treat advanced stage solid tumors are gaining interest after recent clinical successes. The immune checkpoint human leukocyte antigen G (HLA-G) is expressed in several tumor types while in normal tissues expression is limited. Here, we describe JNJ-78306358, a T cell-redirecting bispecific antibody (bsAb) to treat advanced stage solid tumors. JNJ-78306358 binds with high affinity to the α3 subunit of HLA-G on cancer cells and with purposely engineered weaker affinity to CD3ε on T cells. JNJ-78306358 induced potent T cell-mediated cytotoxicity of HLA-G-expressing solid tumors