Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord.

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Tác giả: Matthew J Broadhead, Stephanie A Di Vito, Carlotta Löer, Adam P Lognon, Gareth B Miles, Jonathan J Milla-Cruz, Simon A Sharples, Anchita Shonak, Michelle A Tran, Patrick J Whelan

Ngôn ngữ: eng

Ký hiệu phân loại: 617.482 +Spinal cord

Thông tin xuất bản: United States : iScience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 683119

Spinal circuits generate locomotor rhythms, but the mechanisms behind episodic locomotor behaviors remain unclear. This study investigated dopamine-induced episodic rhythms in isolated neonatal mouse spinal cords to understand these mechanisms. The episodic rhythms were generally synchronous and propagated rostro-caudally, although occasional asynchrony was observed. Electrical stimulation of the L5 dorsal root entrained the episodic rhythms, suggesting afferent control and a distributed network. Even after transection or ventrolateral funiculus (VLF) lesions, episodic activity persisted in isolated thoracic or sacral segments, implying VLF-coupled networks. Rhythmicity was observed in VLF and dorsal root axons and was independent of cholinergic excitation via motoneurons, GABA
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