Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function.

• Tác giả: Xintong Hou, Zheng Hu, Yan-Hou Liu, Tianmeng Sun, Feng Wang, Xue Wang, Guang-Yao Xie, Yanbao Xin, Yong-Guang Yang, Ting Zhang, Wen-Jie Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 598.634 *Tetrao
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 683121

Tóm tắt

Thrombospondin-1 (TSP-1)/CD47 signaling induces cell death and inhibits angiogenesis. Here, we investigated the possibility of improving donor engraftment by blocking the TSP-1/CD47 pathway in mouse models of total body irradiation (TBI)-conditioned syngeneic hematopoietic stem cell transplantation (HSCT). Our findings revealed that HSCT engraftment was improved in mice deficient in CD47 (