Midostaurin-associated perimyocarditis: a case report of severe cardiotoxicity of novel targeted treatments for acute myeloid leukaemia and review of the literature.

• Tác giả: Oliver A Cornely, Alev Kalkan, Lenhard Pennig, Roman Pfister, Jannik Stemler
• Ngôn ngữ: eng
• Thông tin xuất bản: England : European heart journal. Case reports , 2025
• Bộ sưu tập: NCBI
• ID: 683131

Tóm tắt

BACKGROUND: Midostaurin is a multikinase inhibitor for the treatment of Fms-like tyrosine 3 ( CASE SUMMARY: A 24-year-old man with newly diagnosed AML and DISCUSSION: In addition to the most frequently reported non-cardiac adverse effects of midostaurin, serious cardiotoxic complications appear to occur and may require discontinuation of therapy. This case highlights the importance of interdisciplinary work-up of a cardio-oncology pathway even in presumably low-risk patients and particularly in the context of rare cases of cardiotoxicity in novel cancer treatments.