Mutational pressure promotes release of public CD8

• Tác giả: Alexey A Belogurov, Alexey A Bondarev, Ivan O Butenko, Alena S Evpak, Alexander G Gabibov, Vadim M Govorun, Anna A Kudriaeva, Daria S Matyushkina, Yuliana A Mokrushina, Maxim Т Ri, George A Saratov, Ivan V Smirnov
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: United States : iScience , 2025
• Bộ sưu tập: NCBI
• ID: 683152
• Chủ đề: 1. Mutational; 2. Pressure; 3. Promotes

Tóm tắt

The COVID-19 pandemic was the most dramatic in the newest history with nearly 7 million deaths and global impact on mankind. Here, we report binding index of 305 human leukocyte antigen (HLA) class I molecules from 18,771 unique haplotypes of 28,104 individuals to 821 peptides experimentally observed from spike protein receptor binding domain (RBD) of five main SARS-CoV-2 strains hydrolyzed by human proteasomes with constitutive and immune catalytic phenotypes. Our data read that mutations in the human angiotensin-converting enzyme 2 (hACE2)-binding region RBD