Genomic alterations in the WNT/β-catenin pathway and resistance of colorectal cancer cells to pathway-targeting therapies.

• Tác giả: Ioannis A Voutsadakis
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.11228 Engineering mechanics and materials
• Thông tin xuất bản: United States : Exploration of targeted anti-tumor therapy , 2025
• Bộ sưu tập: NCBI
• ID: 683184

Tóm tắt

AIM: Colorectal cancer is the most prevalent gastrointestinal malignancy with limited therapeutic options in the metastatic setting. The WNT/β-catenin/adenomatous polyposis coli (APC) pathway is commonly deregulated in the disease and presents a rational target for therapeutic exploitation. METHODS: The publicly available genomic data from the colorectal cancer cohort of the Cancer Genome Atlas (TCGA) were used to define groups of colorectal cancers with alterations in RESULTS: Three-fourths of colorectal cancers possessed CONCLUSIONS: Groups of colorectal cancers differing in WNT/β-catenin/APC pathway alterations present diverse genomic landscapes that could have therapeutic implications for the rational development of inhibitors of the pathway.