The COVID-19 pandemic has highlighted the critical need for effective antiviral therapies, as viral infections remain a leading cause of mortality worldwide. Natural compounds, especially those derived from plants, have been recognized for their therapeutic properties. Ginseng, in particular, has attracted considerable attention for its potential antiviral effects. This review examines the antiviral compounds from ginseng that act against various human pathogenic viruses. We systematically summarize the antiviral activities of ginseng compounds targeting a range of viruses, including human rhinovirus (HRV), influenza virus, human immunodeficiency virus (HIV), hepatitis viruses A, B, and C (HAV, HBV, HCV), herpes simplex virus (HSV), enterovirus 71 (EV71), coxsackievirus, norovirus, and SARS-CoV-2, the virus responsible for COVID-19. This review covers