Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control.

• Tác giả: Sarah Akhlaghi, Armin Aryannejad, Kamyar Keshavarz, Amirreza Kiani, Samira Kiani, Ryan LeGraw, Samuel LoPresti, Vineet Mahajan, Tahere Mokhtari, Mohammad N Taheri, Kathryn A Whitehead, Yuda Xiang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.75 Sanitation and safety engineering
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683471

Tóm tắt

Temporal transcriptional modulation of immune-related genes offers powerful therapeutic potential for treating inflammatory diseases. Here, we introduce an enhanced zinc finger (ZF)-based transcriptional repressor delivered via lipid nanoparticles for controlling immune signaling pathways