TEAD inhibition alters the lung immune microenvironment and attenuates metastasis.

• Tác giả: Tina Asemi, Rohith Battina, Amber Kiliti, Maha Moussa, Raneen Rahhal, Anna T Riegel, Marcel O Schmidt, Ghada M Sharif, Anton Wellstein
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683513

Tóm tắt

The Hippo pathway signaling mediated through YAP/TAZ, and the transcription factor TEAD is known to be involved in primary tumor progression. Here we report that novel TEAD inhibitors (iTEAD) cause a significant reduction in the outgrowth of lung metastases from triple negative breast cancer (TNBC) models mediated predominantly through changes in stromal immune signaling. TEAD inhibition did not affect the proliferation of TNBC cancer cells