CD4 T cell counts are inversely correlated with anti-cluster A antibodies in antiretroviral therapy-treated PLWH.

• Tác giả: Mehdi Benlarbi, Catherine Bourassa, Antonella Castagna, Tommaso Clemente, Madeleine Durand, Andrés Finzi, Suneetha Gottumukkala, Frank Maldarelli, Halima Medjahed, Marzena Pazgier, Marc-Messier Peet, Jonathan Richard, William D Tolbert
• Ngôn ngữ: eng
• Ký hiệu phân loại: 321.05 *Nation-states
• Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025
• Bộ sưu tập: NCBI
• ID: 683530

Tóm tắt

While antiretroviral therapy efficiently suppresses viral replication, inflammation and immune dysfunction persist in some people living with HIV-1 (PLWH). Soluble gp120 (sgp120) has been detected in PLWH plasma and its presence is linked to immune dysfunction. It was reported that sgp120 binding to CD4 on uninfected bystander CD4