Age-Related Differences in the Choroid Plexus Structural Integrity Are Associated with Changes in Cognition.

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Tác giả: Joseph S R Alisch, Yang An, Jonghyun Bae, Murat Bilgel, Mustapha Bouhrara, Angelique de Rouen, Josephine M Egan, Noam Y Fox, Zhaoyuan Gong, Alex Guo, Alexander Klistorner, Samuel Klistorner, Caio Mazucanti, Susan M Resnick, Nathan Zhang

Ngôn ngữ: eng

Ký hiệu phân loại: 620.11215 Engineering mechanics and materials

Thông tin xuất bản: United States : medRxiv : the preprint server for health sciences , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 683544

The choroid plexus (CP) plays a critical role in maintaining central nervous system (CNS) homeostasis, producing cerebrospinal fluid, and regulating the entry of specific substances into the CNS from blood. CP dysfunction has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. This study investigates the relationship between CP structural integrity and cognitive decline in normative aging, using structural and advanced magnetic resonance imaging techniques, including CP volume, diffusion tensor imaging indices (mean diffusivity, MD, and fractional anisotropy, FA) and relaxometry metrics (longitudinal, T
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