Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence.

• Tác giả: Omar R Ahmad, Marcus L Basiri, Brandy Briones, Jane Y Chen, Koichi Hashikawa, Yoshiko Hashikawa, Kentaro Ishii, Nathan L Johnston, Yuejia Liu, Jenna A McHenry, Rishi V Mukundan, Richard D Palmiter, Mark A Rossi, David R Rubinow, Rhiana C Simon, Jason R Siputro, James C Soetedjo, Garret D Stuber, Larry S Zweifel
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 683557

Tóm tắt

UNLABELLED: Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout the nervous system and periphery. In this study, we investigated the transcriptional dynamics of the medial preoptic area (MPOA), a critical region for reproductive behavior, using single-cell RNA sequencing (scRNAseq) and ONE SENTENCE SUMMARY: Single cell RNA sequencing reveals how adolescent sex hormones sculpt hypothalamic cell types required for mating behavior.